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  • Carotid Artery Plaque Analysis

    Description:
    Stroke is the second leading cause of death throughout the world, and the third leading cause of death in the United States, behind heart disease and cancer. The incidence of stroke has been gradually increasing with the aging population, and the outcome is often detrimental. It has been shown that the greatest impact on this disease comes from early prevention and intervention. The purpose of this study was to establish an area in patients showing no symptoms with moderate carotid stenosis (50-79%) to help identify the individuals and risk factors that lead a patient to a higher risk for stroke. The severity of carotid artery stenosis and plaque composition determine the treatment options. The two imaging modalities utilized in assessing plaque intensity are the Ultrasound and Magnetic Resonance Angiogram (MRA). However, there remained an unknown correlation between components of plaque composition defined by ultrasound versus MRA. My objective was to find the correlation between the two components. With this objective, a hypothesis for the trial was formulated: Ultrasound is equally able to measure plaque volume and heterogeneity when compared with MRA. Twenty subjects who underwent a carotid artery ultrasound and were found to have moderate stenosis, were referred for carotid artery MRA. These imaging modalities assessed percent stenosis severity and plaque heterogeneity index. From the obtained data, the hypothesis was validated as there was no statistical significant difference between plaque volume and heterogeneity of the carotid plaque estimated by either Ultrasound or MRA.
    Subject:
    Biology
    Creator:
    Mendez, Nicole
    Contributor:
    Dr. E. Regina Giuliani, Thesis Advisor
    Owner:
    lsquillante@saintpeters.edu
    Publisher:
    Saint Peter's University
    Date Uploaded:
    10/14/2020
    Date Modified:
    10/14/2020
    Date Created:
    Spring 2013
    Rights Statement:
    In Copyright
    Resource Type:
    Research Paper

  • The effects of microwave and cell phone radiation on ocular development in Xenopus laevis tadpoles

    Description:
    The experiment was performed to determine the effects of microwave and cell phone radiation on ocular development and lens opacity in Xenopus laevis tadpoles. Our model system for these studies is the amphibian developing retina, a derivative of the diencephalon of the forebrain. In order to examine the tadpoles, MS-222 was used as an anesthetic. To induce amplexus, we injected 500 IU of chorionic gonadotropin into the dorsal lymph sacs of both male and female Xenopus laevis. Embryos were exposed to microwave and cell phone radiation during all stages of embryonic development. Morphological changes in the developing eye were monitored photographically and a qualitative assay was used to assess lens opacity. Results from the experiments have been inconclusive. Deaths of tadpoles were experienced but were tied to outside circumstances.
    Subject:
    Biology
    Creator:
    Watson, Aubrey
    Contributor:
    Dr. E. Regina Giuliani, Thesis Advisor
    Owner:
    lsquillante@saintpeters.edu
    Publisher:
    Saint Peter's University
    Date Uploaded:
    10/14/2020
    Date Modified:
    10/14/2020
    Date Created:
    Spring 2013
    Rights Statement:
    In Copyright
    Resource Type:
    Research Paper