In recent years, scientists have come to understand that the effective life span of antimicrobial agents is limited, due to the current crisis pertaining to the rapid emergence of resistant bacteria that is occurring worldwide. As a result, numerous studies have been, and continue to be, conducted in order to find natural alternative sources of antimicrobial agents, with particular interest in sourcing them from plants. The aim of this study is to explore the inhibitory effects of limonene and holy basil tea on Staphylococcus epidermidis biofilms, as well as to observe any synergistic interactions between these agents and the broad-spectrum antibiotic tetracycline that may amplify the inhibition of these biofilms. Limonene and holy basil tea are both plant-based treatments, sourced from the oil of citrus fruits, and from holy basil, respectively. A traditional crystal violet (CV) biofilm assay was used to test the effectiveness of these agents in inhibiting the growth of S. epidermidis biofilms. Trends thus far indicate that these test agents possess antibacterial activity with which to inhibit the formation of S. epidermidis biofilms.