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  • The Effects of Creatine Monohydrate on Renal Function in Wistar Rats

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    Description:
    Creatine is a supplement taken to aid athletes and fitness aficionados alike with their workout. Previous studies have been done to prove the effects creatine has on a workout as well as studies on rats to investigate the benefits of creatine on different aspects of health, mainly the nervous system; however, there is minimal data available about the risks. Wistar rats are excellent subjects for human related studies due to the mammalian traits shared between them. Protein over-consumption affects the kidneys and bone via calcium loss; this is a concern with creatine since it is a protein. The rats in the control group did not consume creatine while the rats in the experimental group consumed 1g.kg-1. per day for four weeks. Their urine was collected tested for calcium andd protein weekly. .Increased concentrations were indicative of renal damage. At the end of the four weeks, the rats were euthanized and the kidneys of each were examined in order to best determine the extent of predicted damage to the kidneys. In order to ensure that creatine use was not being overestimated, a research survey was conducted on thirty six members of the Saint Peter's University Biology Department of varying ages yielding results that 22.2% of participants use/have used creatine and 62.5% of those participants used the supplement for 2 months or more.
    Keyword:
    renal function, medicine, and creatine monohydrate
    Creator:
    Kelly, Laura
    Contributor:
    Dr. Laura Twersky, Thesis Advisor
    Owner:
    lsquillante@saintpeters.edu
    Publisher:
    Saint Peter's University
    Date Uploaded:
    10/23/2019
    Date Modified:
    10/23/2019
    Date Created:
    May 2016
    Rights Statement:
    In Copyright
    Resource Type:
    Research Paper

  • Inhibitory Effects of Probiotics on the Growth of Biofilms: A Review

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    Description:
    This review examines the role probiotics can play in reducing and inhibiting the growth of biofilms that cause bacterial infections in humans. The use of probiotics as an inhibitory agent against biofilms is a new field of study that requires further research. As of now, there is little research or scientific literature to defend the health claims of several commercially sold probiotics. Also, biofilms are a fairly new field of study even though biofilms are the cause of most bacterial infections. Since biofilms have an increased antibiotic resistance, it has become increasingly more important to find alternative treatments for bacterial infections. However, there have been a couple of studies that have shown positive results for probiotics inhibiting the growth of different types of biofilms such as Lactobacillus acidophilus in patients with dental caries caused by the biofilm formation of Streptococcus mutans. Specifically, the biosurfactant of the probiotic was used to disrupt the biofilm. Another study was done on patients with Clostridium difficile infection who showed a decline in symptoms when treated with the probiotic yeast Saccharomyces boulardii as an additive to antibiotic treatments . While the oral health and gut health fields have started to utilize the benefits of probiotics, the effect of probiotics on the biofilms that cause infections for patients with medical devices has yet to be studied.
    Keyword:
    probiotics, biofilm, and medicine
    Creator:
    Collins, Schieler
    Contributor:
    Dr. Jill Callahan, Thesis Advisor
    Owner:
    lsquillante@saintpeters.edu
    Publisher:
    Saint Peter's University
    Date Uploaded:
    10/23/2019
    Date Modified:
    10/23/2019
    Date Created:
    May 2019
    Rights Statement:
    In Copyright
    Resource Type:
    Research Paper